Zwitterionic co - crystals
نویسنده
چکیده
Zwitterionic co-crystals family could be basis for very different structural and theoretical examinations as their ability to alter solubility and deliver a wide solubility spectrum is receiving more attention. Many zwitterionic co-crystals crystal structures exhibited carboxylate-hydroxyl supramolecular heterosynthons preference. In addition to examples of zwitterionic co-crystals in the Cambridge Structural Database, L-phenylalanine/fumaric acid, saccharin-piroxicam, gabapentin-oxalic acid, piroxicamfumaric acid, β-alanine-oxalic acid-water, γ-aminobutyric acid-oxalic acid, 1,1-dicyano-2-(4-hydroxyphenyl)-ethene:L-proline, L-Proline:2,5-dihydroxybenzoic acid, co-crystals of amino acid zwitterions and Li salts, polyphenol with zwitterions (betaine, sarcosine, dimethyl glycine, baclofen, nicotinic acid, isonicotinic acid), and glycine-trimesic acid monohydrate have been reported. The ionization states of the compounds at different pH values need to be examined in order to produce cocrystals. It is hoped that zwitterionic co-crystals have potential scope in drug delivery.
منابع مشابه
The formation of a hydrated homochiral helix from an achiral zwitterionic salt, spontaneous chiral symmetry breaking and redox chromism of crystals.
A unique supramolecular helix assisted by water tetramers is obtained by static evaporation of aqueous solution of a zwitterionic salt, 1,1'-bis(4-carboxylatebenzyl)-4,4'-bipyridinium; spontaneous chiral symmetry breaking occurs in crystallization; interestingly, redox chromism behavior of crystals upon exposure to alcohol atmosphere has been observed.
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